Enhancing Anti-Infective Activity through Structural Adaptability and Synthesis of Quinolone Analogues: Comprehensive Review

Fluoroquinolones (FQs) are a widely used class of antibacterial agents, renowned for their excellent physicochemical and pharmacokinetic properties. Their flexibility in synthesis and ease of modification have led to the development of therapeutically beneficial analogues with improved antibacterial activities. Interestingly, recent studies have shown that certain derivatives of ciprofloxacin and norfloxacin exhibit enhanced anticancer properties in different kinds of cancer cells. This project goal is to investigate the structure-activity relationship of fluoroquinolone derivatives, focusing on their antimicrobial and anticancer potential. In order to combat urinary tract infections (UTIs), the project will investigate the creation of new FQ derivatives with enhanced antibacterial properties. prevalent and debilitating condition. Additionally, the anticancer properties of these derivatives will be evaluated, with the ultimate goal of identifying promising leads for the treatment of UTIs and cancer. The results of this study might help create more focused and efficient treatments, tackling the rising issues of cancer therapy and antibiotic resistance.