Synthesis and Antifungal Activity of Some Bis-1,4-(3-Mercapto-5-Oxymethyl-1,2,4-Triazole-5-yl) Benzene & Bis-1,4-(5-Amino-2-Oxymethyl-1,3,4-Thiadiazole-2-yl) Benzene

Heterocyclic compounds are well known for their pharmacological application.Among all Ncontaining heterocyclic compounds, triazole emerges superior application.Triazole have two core structures 1,2,4-triazole and 1,2,3-triazoles.They both can give a broad range of substitutions with their structures, due to these characteristics, they have significant biological applications.They are also important in organocatalysis, agrochemicals, and material science.We aim to explore suitable molecular modifications in thiadiazole and triazole derivatives to enhance their pharmacological profiles.This paper outlines the methodology used to investigate the structure and antifungal properties of heterocyclic compounds derived from hydroquinone.The synthesis included compounds, such as Bis-1,4-(3-mercapto-5-oxymethyl-1,2,4-triazole-5-yl) benzene and Bis-1,4-(5-amino-2-oxymethyl-1,3,4thiadiazole-2-yl) benzene.To confirm the structures of these newly synthesized compounds, gravimetric analysis, melting point determination, elemental analyses, and infrared (IR) spectra (recorded using KBr) were conducted using a Perkin-Elmer spectrometer.Additionally, NMR spectra were obtained in DMSO-d6 on an EM-360 spectrometer (60 MHz), using TMS as the internal standard.The antifungal efficacy of these compounds was evaluated against Aspergillus flavus, Helminthosporium tetramera, and Penicillium decumbens by the paper disc plate method at concentration levels of 2.0 and 0.2% (w/v) in dimethyl sulfoxide standard PDA medium.