Biodegradable Devices Based on Blends of Polylactide and Polycaprolactone and Their Copolymers for the Closure of Fibrosis Annulus Defects after Sequestrectomy of the Intervertebral Disc
Several types of devices are proposed for closing annulus fibrosus defects after sequestrectomy to restore the biomechanics of the intervertebral disc. Polylactide, poly-ε-caprolactone, and copolymers of lactide and ε-caprolactone are selected as the materials. The compressive modulus values of the materials range from 0.54 to 210 MPa, depending on the composition and structure of the devices being developed. Sponge-type devices made from copolymers of polylactide and polycaprolactone show the most promise for further in vivo research studies.
Authors
- Varvara A. Demina (ORCID: https://orcid.org/0009-0003-7302-1048)
- T. Е. Grigoriev (ORCID: https://orcid.org/0000-0001-8197-0188)
- С. Н. Чвалун (ORCID: https://orcid.org/0000-0001-9405-4509)
- A. A. Stupnikov (ORCID: https://orcid.org/0000-0003-1711-9756)
- Petr V. Dmitryakov (ORCID: https://orcid.org/0009-0006-7596-0489)
- M. M. Alexanyan (ORCID: https://orcid.org/0000-0003-1321-086X)
- Yu. S. Fomina (ORCID: https://orcid.org/0009-0009-0297-0397)
- Yu. D. Zagoskin (ORCID: https://orcid.org/0000-0002-5825-8333)
- С. Н. Малахов (ORCID: https://orcid.org/0000-0002-9015-2117)
- А. А. Несмелов
- S. A. Makarov (ORCID: https://orcid.org/0000-0001-7237-240X)
Institutions
- Moscow Institute of Physics and Technology (RU)
- Moscow Power Engineering Institute (RU)
- Kurchatov Institute (RU)
- Institute of Physics and Technology (RU)
- Institute of Synthetic Polymeric Materials (RU)
- Russian Scientific Center of Surgery (RU)
- Moscow Aviation Institute (RU)
Publication Details
- Journal
- Nanobiotechnology Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1134/s2635167624602158
- Citations
- 1
- Primary Topic
- biodegradable polymer synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.60