0499 Use of an integrated multi-omics approach to unlock advantage of natural products for tone management: San Bai Decoction as case study

Increasing concern of skin disorders has resulted in high demand for the development of superior cosmetic products. TCM formulae (consisting of 2 or more medicinal herbs) has been used over thousands of years for maintaining healthy aging, beauty and wellbeing in China. Therefore, it’s critical to discover its scientific significances of synergistic effects of TCM formulae and underlying mechanisms from perspective of systems biology. The aim of our study was to demonstrate the importance of the network pharmacology combined with multi-omics analysis in developing cosmeceuticals from TCM by using San Bai Decoction (poria, licorice, peony and atractylodes, SBD) as case study.