0498 Single cell analysis of hidradenitis suppurativa compared to Crohn’s disease

Hidradenitis suppurativa (HS) and Crohn’s disease (CD) are chronic inflammatory disorders affecting distinct anatomical regions yet exhibiting shared phenotype. HS manifests as a skin condition characterized by the formation of deep abscesses and tunnel formation in intertriginous areas, while CD primarily affects the gastrointestinal tract. Despite clinical and immunological overlaps, the precise mechanisms driving fistula formation, a hallmark of both conditions, remain poorly understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on inflamed skin biopsies from HS patients (n=16) and intestinal biopsies from CD patients (n=24) to delineate the common pathologic loop underlying fistula generation.