Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension
Overlapping and distinct gene expression patterns exist in SSc-PAH versus IPAH, with significant molecular differences suggesting unique pathogenic mechanisms in SSc-PAH. These findings highlight the potential for precision-targeted therapies to improve outcomes in patient with SSc-PAH. Future studies should validate these targets and explore their therapeutic efficacy.
Authors
- Rachel L. Damico (ORCID: https://orcid.org/0000-0002-2584-1557)
- Karthik Suresh (ORCID: https://orcid.org/0000-0003-2920-0949)
- Micheala A. Aldred (ORCID: https://orcid.org/0000-0002-7390-9181)
- Julie Coursen (ORCID: https://orcid.org/0009-0003-4847-6876)
- Larissa A. Shimoda (ORCID: https://orcid.org/0000-0001-5987-1378)
- Michael P. Croglio
- Tammy Graves
- Paul M. Hassoun (ORCID: https://orcid.org/0000-0003-0601-4975)
- Shannon Niedermeyer (ORCID: https://orcid.org/0000-0003-1804-7125)
- Stephen C. Mathai (ORCID: https://orcid.org/0000-0003-3188-7209)
- Sarah Khan (ORCID: https://orcid.org/0000-0002-6934-8297)
- Catherine E. Simpson (ORCID: https://orcid.org/0000-0002-2388-5660)
- Todd M. Kolb (ORCID: https://orcid.org/0000-0003-0524-7400)
- Darin Rosen (ORCID: https://orcid.org/0009-0001-5352-9288)
- Tijana Tuhy (ORCID: https://orcid.org/0000-0002-8922-9471)
- Christopher Cherry (ORCID: https://orcid.org/0000-0002-5481-0055)
- Michael Patatanian
- Mohab Elnashar
Institutions
- Ain Shams University (EG)
- University of Miami (US)
- Norwegian Womens Public Health Association (NO)
- Pulmonary and Critical Care Associates (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1161/circgen.124.004936
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04