Neonatal and 3-month cerebrovascular oxygenation, stability, and extraction in congenital heart disease versus control infants
CHD infants had persistently poorer indices of cerebrovascular health (i.e., lower rcSO<sub>2</sub>, increased FTOE, and reduced cerebrovascular stability) through the 3-month age compared to controls. Sustained cerebral hypoxia, reduced cerebrovascular stability, and increased FTOE may contribute to neurodevelopmental delays (NDDs) and could serve as early biomarkers for identifying infants at higher risk for NDD.
Authors
- Anthony Colombo (ORCID: https://orcid.org/0000-0002-4981-1651)
- Jodie K. Votava‐Smith (ORCID: https://orcid.org/0000-0002-8934-5333)
- Panteha Hayati Rezvan (ORCID: https://orcid.org/0000-0001-6360-8388)
- Andrew T. Pham
- Nhu Tran (ORCID: https://orcid.org/0000-0002-3429-6415)
- Ken M. Brady (ORCID: https://orcid.org/0000-0002-3260-0233)
- John C. Wood (ORCID: https://orcid.org/0000-0003-0996-3439)
- Joanne Y. W. Yip (ORCID: https://orcid.org/0000-0002-3270-4702)
- Bradley S. Peterson (ORCID: https://orcid.org/0000-0001-5737-225X)
- Mary‐Lynn Brecht (ORCID: https://orcid.org/0000-0003-2540-5883)
- Philippe Friedlich (ORCID: https://orcid.org/0000-0002-8944-2432)
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Lurie Children's Hospital (US)
- Children's Hospital of Los Angeles (US)
- University of California, Los Angeles (US)
- California Southern University (US)
- University of California System (US)
Publication Details
- Journal
- Journal of Clinical and Translational Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/cts.2025.10106
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital Los Angeles
- Southern California Clinical and Translational Science Institute
- Sigma Theta Tau International
- National Institutes of Health
- University of California, Los Angeles
- National Institute of Nursing Research
- National Center for Advancing Translational Sciences