Antibacterial Activity of Polyvinylidene Fluoride/polyethylene Oxide Nanofibers Loaded with Azithromycin for Wound Dressing

Treating skin injuries remains challenging due to issues like wound infections.In this study, polyvinylidene fluoride (PVDF)/polyethylene oxide (PEO)/azithromycin (AZ) composite nanofibers were prepared using electrospinning to reduce bacterial infections in skin wounds.The surface morphology, chemical structure, and hydrophilicity of the nanofibers were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and contact angle measurements, respectively.Antibacterial performance tests revealed that increasing the AZ dosage expanded the antibacterial zone, indicating improved effectiveness.Furthermore, experiments on rat skin infections showed that the PVDF/PEO/AZ membrane inhibited suppuration at S. aureus-infected wound sites.These findings demonstrate the potential of AZ-loaded PVDF/PEO nanofiber membranes as effective antibacterial dressing.