Depressive symptoms in adolescents with and without polycystic ovary syndrome living with obesity: a case-control study

Depressive symptoms are extremely common in adolescents with or without PCOS and matched BMI, suggesting that obesity is not the only mechanism leading to depression. The mechanisms leading to depression in adolescents with PCOS, including relationships between metabolic profiles, PCOS, and depression, require further exploration to personalize therapy in this group of particularly vulnerable individuals.