Glucose Metabolism Recoding Regulates the Correa Cascade Response: An Important Strategy for Gastric Cancer Prevention and Treatment in Traditional Chinese Medicine

胃癌是最常见的恶性肿瘤之一，Correa级联反应模式将胃癌的发展大致分为胃炎、胃癌前病变和胃癌三个阶段。在影响胃癌Correa级联反应发展的各类因素中，葡萄糖代谢重编码发挥着重要作用。本文总结了葡萄糖代谢重编码在胃癌Correa级联反应中的动态变化和分子机制，葡萄糖代谢重编码与自噬、上皮间充质转化、铁死亡和氧化应激通过相互串扰促进胃癌Correa级联反应。综上所述，中医在靶向葡萄糖代谢调控防治胃癌的Correa级联反应方面具有多靶点、多途径、疗效确切和副作用少的特点。Gastric cancer is one of the most common malignant tumors, and the Correa cascade response model broadly classifies the development of gastric cancer into three stages: gastritis, gastric precancerous lesions and gastric cancer. Among the factors affecting the development of Correa cascade response in gastric cancer, glucose metabolic recoding plays an important role. In this paper, we summarize the dynamic changes and molecular mechanisms of glucose metabolic recoding in the Correa cascade response of gastric cancer, and glucose metabolic recoding and autophagy, epithelial mesenchymal transition, iron death and oxidative stress promote the Correa cascade response of gastric cancer through mutual crosstalk. It is concluded that TCM has the characteristics of multi-targets, multi-pathways, precise efficacy and few side effects in targeting glucose metabolism regulation to prevent and control Correa cascade response in gastric cancer.