Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation

Our findings indicate that FAP concentrations do not reflect radiation-induced inflammation or fibrosis in the early period after radiation therapy. The small patient cohort and short duration between radiation therapy and FAP measurement may have limited our ability to detect changes in FAP related to long-term radiation effects. Further research with larger cohorts and longer follow-up periods is needed to better understand the role of FAP in cancer and response to radiation injury.