Prognostic Impact of Lymph Node Yield in a Phase III Clinical Trial (NRG/RTOG 9601) of Prostate Cancer Patients Treated With Salvage Radiation Following Prostatectomy
Although lymph node yield in NRG/RTOG 9601 did not show association with adverse outcomes in the entire cohort or either arm alone, there was significant association between lymph node yield and adverse outcomes when seminal vesicle invasion was present. The therapeutic benefit of extensive lymph node dissection remains uncertain but could be more relevant in higher risk patients.
Authors
- William U. Shipley (ORCID: https://orcid.org/0009-0008-0887-8391)
- Thomas M. Pisansky
- Seth A. Rosenthal (ORCID: https://orcid.org/0000-0003-0950-2261)
- Jeffry Simko
- Robert Timothy Dess (ORCID: https://orcid.org/0000-0003-2331-3758)
- Lyudmila DeMora
- Howard M. Sandler (ORCID: https://orcid.org/0000-0002-8193-5769)
- Emily Chan (ORCID: https://orcid.org/0000-0002-7290-4004)
- Jason A. Efstathiou (ORCID: https://orcid.org/0000-0003-0996-0350)
- Elizabeth Gore
- Anthony Wong (ORCID: https://orcid.org/0000-0002-9288-061X)
- Jean‐Paul Bahary
- Himanshu Lukka
- Kenneth L. Zeitzer (ORCID: https://orcid.org/0000-0001-5206-9956)
- Felix Y. Feng (ORCID: https://orcid.org/0000-0001-9756-4037)
- Alexander G. Balogh
- Michael Kuettel
- L.S. McGinnis
- R.D. Lovett
- Stephanie L. Pugh (ORCID: https://orcid.org/0000-0002-5977-8912)
Institutions
- Cedars-Sinai Medical Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Mayo Clinic (US)
- Harvard University (US)
- Medical College of Wisconsin (US)
- University of Michigan (US)
- Thomas Jefferson University Hospital (US)
- Juravinski Cancer Centre (CA)
- Rutland Regional Medical Center (US)
- Massachusetts General Hospital (US)
- Michigan Center for Translational Pathology (US)
- Sutter Roseville Medical Center (US)
- Novant Health Presbyterian Medical Center (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- NRG Oncology (US)
- Hamilton Health Sciences (CA)
- University of San Francisco (US)
- Stanford University (US)
Publication Details
- Journal
- The Prostate
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1002/pros.70018
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NRG Oncology
- National Cancer Institute