Access to SCF₃-Substituted Indolizines via a Photocatalytic Late-Stage Functionalization Protocol

A mild, scalable, and highly chemoselective photocatalytic method was developed for direct indolizine functionalization with <i>N</i>-((trifluoromethyl)thio)saccharin, yielding high amounts of desired products while tolerating various functional groups. The photoredox catalyst employed offers a straightforward and inexpensive alternative to commercially available catalysts. Additionally, a 3-SCF₃ analogue of a histamine H3 receptor antagonist was synthesized with excellent yield, demonstrating the strategy's potential in developing biologically relevant molecules.