Analysis of the optimal patterns of serum alpha fetoprotein (AFP), AFP-L3% and protein induced by vitamin K absence or antagonist-II (PIVKA-II) detection in the diagnosis of liver cancers
For serum AFP, AFP-L3% and PIVKA-II, diagnostic models of combined marker detection improved efficacy in the diagnosis of liver cancers. Diagnostic models GALAD, ASAP, GALAD-C and C-GALAD showed the highest efficacy in the diagnosis of HCC, overall liver cancers (HCC + CCA) and early liver cancers, and can be used preferentially in clinical practice.
Authors
- Ling Luo (ORCID: https://orcid.org/0000-0002-7924-415X)
- Haixiong Lin
- Xing Xuan (ORCID: https://orcid.org/0000-0002-4648-1861)
- Xiaochen Wang (ORCID: https://orcid.org/0000-0002-4344-0925)
- Chaohui Duan (ORCID: https://orcid.org/0000-0003-3130-5045)
- Xi Peng (ORCID: https://orcid.org/0000-0001-5020-2792)
- Xianghua Lin
- Robert Zhong (ORCID: https://orcid.org/0000-0002-6422-0526)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-07-21
- DOI
- https://doi.org/10.7717/peerj.19712
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Sun Yat-sen University