Role of homovanillic acid esters in the regulation of skin inflammatory pathways and their effect on tight junction protein expression
The results suggest that the homovanillic ester-induced CLDN1 upregulation is a result of increased differentiation of the basal keratinocytes towards the keratinocyte morphology present in the stratum granulosum (SG), where tight junctions are formed. In conclusion, homovanillic acid esters with a 5 or 6 C-atom long aliphatic chain induced CLDN1 expression, thereby stimulating keratinocyte differentiation, independent from TRPV1 activation.
Authors
- Veronika Somoza (ORCID: https://orcid.org/0000-0003-2456-9245)
- Barbara Lieder (ORCID: https://orcid.org/0000-0002-0527-8330)
- Dominik Stuhlmann
- Joachim Hans
- Maria Fernanda Cervantes Recalde
- Elena Zoe Bogensperger
Institutions
- University of Hohenheim (DE)
- University of Vienna (AT)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Symrise (Germany) (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fphar.2025.1629941
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Universität Hohenheim
- Symrise