Accurate Neurotransmitter Release by Ultrasound‐Responsive Nanomaterials for Alleviating L‐DOPA‐Induced Dyskinesia in Parkinson's Disease
Functional nanomaterials show great promise in next-generation targeted non-genetic neuromodulation and on-demand neurotransmitter release with superior spatiotemporal accuracy. L-DOPA-induced dyskinesia (LID) is a common complication during the treatment process of Parkinson's disease. Dysfunction in the dynamics of dopamine release plays a pivotal role in the disease. A strategy for LID treatment by using ultrasound-responsive functional nanomaterials for controlled release of nitric oxide is proposed, which can activate the nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signaling pathway. This alleviates the abnormal synaptic plasticity caused by excessive and pulsatile dopamine, and diminishes hypersensitivity of the D<sub>1</sub> dopamine receptors, thereby reducing the behavioral disorders associated with LID. These findings offer a novel perspective for therapy of neurodegenerative diseases.
Authors
- Qun‐Dong Shen (ORCID: https://orcid.org/0000-0003-0968-8051)
- Shengwei Jia (ORCID: https://orcid.org/0000-0002-4559-8646)
- Fang Wang (ORCID: https://orcid.org/0000-0001-7030-0023)
- Hao Zhang (ORCID: https://orcid.org/0000-0003-0693-2880)
- Xiaoxia Li (ORCID: https://orcid.org/0000-0002-4872-9525)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Ingenierie des Materiaux polymeres (FR)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1002/adhm.202501765
- Citations
- 1
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Nanjing University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities