High prevalence of methotrexate intolerance in rheumatoid arthritis patients: a cross-sectional study
Although MTX is the one of the most commonly used medication for the treatment of RA, there is significant intolerance to this drug among adult RA patients. The symptoms observed not only occur after MTX intake but are also present before intake (anticipatory) and while thinking of taking MTX (associative). Our data indicates that a MTX dose of 15 mg/week or greater may be associated with intolerance. There is a need to objectively monitor RA patients to identify MTX intolerance early on to ensure mitigation steps for effective treatment response.
Authors
- Nirmal Kumar Ganguly (ORCID: https://orcid.org/0000-0003-2233-9673)
- Shivani Arora Mittal (ORCID: https://orcid.org/0000-0001-9734-3488)
- Harjit Singh Nalwa
- Tushar Singh Barwal (ORCID: https://orcid.org/0000-0002-9989-4790)
- Ved Chaturvedi
- Lalit Duggal (ORCID: https://orcid.org/0000-0002-1164-021X)
- Parul Chugh (ORCID: https://orcid.org/0000-0002-0582-0249)
- Neha Singh (ORCID: https://orcid.org/0000-0001-9137-1103)
- Neeraj Jain (ORCID: https://orcid.org/0000-0003-2776-8012)
Institutions
- Department of Biotechnology (IN)
- Sir Ganga Ram Hospital (IN)
Publication Details
- Journal
- BMC Rheumatology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s41927-025-00466-2
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 6.67