Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood
This study identified distinct alterations in umbilical cord blood KP metabolite concentrations in pregnancies with preeclampsia, FGR, DM, and GDM, but not AIS. This suggests differential regulation and activation of the KP depending on the pregnancy disorder. Such changes may influence maternal and infant health and could play a role in fetal programming, with potential long-term effects on child development and health.
Authors
- Heike Allenberg
- A.H. Jan Danser (ORCID: https://orcid.org/0000-0002-5052-3585)
- Irwin Reiss (ORCID: https://orcid.org/0000-0002-9474-6895)
- Zongye Cai (ORCID: https://orcid.org/0000-0002-4898-1907)
- Anja Lange (ORCID: https://orcid.org/0000-0003-3585-2361)
- Daphne Merkus (ORCID: https://orcid.org/0000-0002-4852-831X)
- Martijn van Faassen (ORCID: https://orcid.org/0000-0002-9142-6263)
- Michelle Broekhuizen (ORCID: https://orcid.org/0000-0002-4736-398X)
- Sofie K M van Zundert (ORCID: https://orcid.org/0000-0002-9369-873X)
- Matthias Heckmann (ORCID: https://orcid.org/0000-0002-5260-264X)
- Claude P. van der Ley
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Universitätsmedizin Greifswald (DE)
- Erasmus MC (NL)
- Universität Greifswald (DE)
- German Centre for Cardiovascular Research (DE)
- Centre of Experimental Medicine of the Slovak Academy of Sciences (SK)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s12958-025-01436-6
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00