The role of Bergamot Polyphenolic Fraction (BPF) in MASLD-Induced HFpEF: Mitigate diastolic dysfunction by targeting chronic low-grade inflammation
Our results demonstrated that BPF improved diastolic dysfunction and reduced chronic low-grade inflammation. Since this inflammatory state is a key predisposing factor for the HFpEF, BPF supplementation emerged as a potential therapeutic strategy to alleviate early MASLD-related inflammation and pathological changes that contribute to the onset of cardiac dysfunction.
Authors
- Vincenzo Mollace (ORCID: https://orcid.org/0000-0002-0392-7173)
- Antonio Cardamone (ORCID: https://orcid.org/0000-0002-9091-1806)
- Rocco Mollace (ORCID: https://orcid.org/0000-0002-7106-5595)
- Anna Rita Coppoletta
- Cristina Carresi (ORCID: https://orcid.org/0000-0002-3509-5930)
- Vincenzo Musolino (ORCID: https://orcid.org/0000-0003-4177-534X)
- Annamaria Tavernese (ORCID: https://orcid.org/0000-0002-2940-3482)
- Micaela Gliozzi
Institutions
- University of Rome Tor Vergata (IT)
- Università Campus Bio-Medico (IT)
- Magna Graecia University (IT)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1016/j.biopha.2025.118375
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Regione Calabria