Plastic additive bisphenol S induces depression by promoting AZU1/CTSD proteins to mediate plasma-related proteins and metabolites: A comprehensive multi-omics analysis
This study elucidates the mechanistic pathways through which the plastic additive BPS induces depression, providing critical insights into its adverse effects on the brain. These findings hold significant implications for public health safety and offer a comprehensive research framework and novel perspectives for evaluating the safety of plastic additives.
Authors
- N. Li
- Yixuan Zeng
- Bing Deng (ORCID: https://orcid.org/0009-0009-0830-4686)
- Chaohua Luo (ORCID: https://orcid.org/0000-0002-2967-1399)
- Yufeng Gu (ORCID: https://orcid.org/0000-0003-1196-6997)
- Yi Liu (ORCID: https://orcid.org/0000-0002-2051-440X)
- Yanhong Ma
- Peng Xie (ORCID: https://orcid.org/0000-0002-4763-7207)
- S W Lu
Institutions
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Jiangmen Central Hospital (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118717
- Citations
- 3
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Provincial Key Laboratory for Translational Cancer Research of Chinese Medicine, Guangzhou University of Chinese Medicine
- Zhejiang Traditional Chinese Medicine Administration