Synthesis, Characterization, and Catalytic Application of Novel Magnetically Separable Fe <sub>3</sub> O <sub>4</sub> @SiO <sub>2</sub> ‐Pr‐NH‐TDI‐VB1 for Rapid Synthesis of Hydrazinyl Thiazoles
ABSTRACT In this work, we report novel thiamine hydrochloride functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 ‐Pr‐NH‐TDI‐VB1) for catalytic applications. The catalytic potential of Fe 3 O 4 @SiO 2 ‐Pr‐NH‐TDI‐VB1 was assessed in the one‐pot three‐component reaction of phenacyl bromide, thiosemicarbazide, and aryl aldehyde for the synthesis of hydrazinyl thiazole in EtOH:H 2 O (50:50, v/v ) at room temperature. The present method exhibits the advantages of a simple reaction procedure, reduced reaction time, efficient retrieval of catalyst for the five runs using an external magnet, ambient reaction condition, and excellent yields. The resultant hydrazinyl thiazoles were purified by simple recrystallization using ethanol.
Authors
- S.R. Mane
- Shankar Hangirgekar (ORCID: https://orcid.org/0000-0003-3723-8509)
- Rutuja Zond (ORCID: https://orcid.org/0000-0002-1047-8839)
- Sandeep Sankpal (ORCID: https://orcid.org/0000-0001-8209-5899)
- Reshma Yadav
- Vishvjeet Havaldar
- Unnati Sasane
- Bhaveshwari Budake
Institutions
- Shivaji University (IN)
Publication Details
- Journal
- Applied Organometallic Chemistry
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1002/aoc.70299
- Citations
- 1
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Science and Engineering Research Board