JMJD8 overexpression in breast cancer: implications for diagnosis, prognosis, and immune microenvironment interactions

The elevated expression of JMJD8 in breast cancer tissues is indicative of its involvement in the progression of the disease and its association with immune cell infiltration patterns. Our findings support the hypothesis that JMJD8 could serve as a prognostic biomarker, reflecting the immunosuppressive characteristics of the tumor microenvironment and aiding in the development of targeted therapeutic strategies for breast cancer management.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-07-21
DOI
https://doi.org/10.3389/fonc.2025.1536278
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00

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article

JMJD8 overexpression in breast cancer: implications for diagnosis, prognosis, and immune microenvironment interactions

Tianyi Xi, Jiwei Cao, Wen Lü, Sentai Wang et al.
1 links
Frontiers in Oncology
interferon and immune responses
article

JMJD8 overexpression in breast cancer: implications for diagnosis, prognosis, and immune microenvironment interactions

Tianyi Xi, Jiwei Cao, Wen Lü, Sentai Wang, Chenlei Zhu, Guorong Yang
article en

Abstract

The elevated expression of JMJD8 in breast cancer tissues is indicative of its involvement in the progression of the disease and its association with immune cell infiltration patterns. Our findings support the hypothesis that JMJD8 could serve as a prognostic biomarker, reflecting the immunosuppressive characteristics of the tumor microenvironment and aiding in the development of targeted therapeutic strategies for breast cancer management.

Frontiers in OncologyVol. 15
Suzhou Municipal Hospital (CN)
Suzhou Municipal Health Commission, Science and Technology Program of Suzhou
Openalex Percentile: Top 81%
interferon and immune responses
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