Research Progress on the Synthesis of Fluorenone and Its Derivatives

芴酮化合物以[6-5-6]三个环系为核心骨架，化学式为C13H8O。其结构由两个苯环通过一个五元环连接而成，五元环上含有一个羰基(C=O)。分子整体呈现平面结构，苯环与五元环共平面，形成稳定的共轭体系。凭借其独特的平面共轭结构和丰富的化学性质，芴酮类化合物在科学研究和工业应用中占据着重要地位。近年来，随着对这些活性化合物研究的深入，芴酮及其衍生物的合成方法得到了不断发展，尤其是绿色化学方法和新型催化剂的使用，推动了其合成技术的创新。本综述将总结近年来芴酮及其衍生物的合成方法，包括经典的合成策略、新型反应机制和绿色合成方法，旨在为该领域的研究者提供参考和启示。Fluorenone compounds feature a [6-5-6] fused ring system as their core skeleton, with the chemical formula C13H8O. Their structure consists of two benzene rings connected by a five-membered ring containing a carbonyl group (C=O). The molecule adopts a planar geometry, with the benzene rings and the five-membered ring lying coplanar to form a stable conjugated system. Owing to their unique planar conjugated structure and versatile chemical properties, fluorenone derivatives hold significant importance in both scientific research and industrial applications. In recent years, with deepening investigations into these bioactive compounds, synthetic methodologies for fluorenone and its derivatives have undergone continuous advancements, particularly through the adoption of green chemistry approaches and novel catalysts, driving innovation in synthetic techniques. This review summarizes recent progress in the synthesis of fluorenone and its derivatives, encompassing classical synthetic strategies, emerging reaction mechanisms, and sustainable methodologies, aiming to provide insights and inspiration for researchers in this field.