Molecular characteristics and antimicrobial susceptibility of carbapenem-resistant Klebsiella pneumoniae in a multicenter study in Ningbo, China
In the Ningbo region, CR-KP is predominantly of the ST11-KL64 type, exhibiting both strong antimicrobial resistance and high virulence characteristics. Non-ST11 CR-KP isolates carry genetically diverse carbapenemase genes and mobile genetic elements (e.g., IncX3, ColKP3). ST11 CR-KP strains demonstrate significantly stronger resistance profiles compared to non-ST11 strains. Therefore, stringent control over the use of carbapenem antibiotics is essential, along with measures to prevent the spread of resistance plasmids and the continuous improvement of hospital infection control strategies.
Authors
- Zheng Yu Bao
- Hongfei Shi (ORCID: https://orcid.org/0000-0003-2314-1386)
- Qian Sun (ORCID: https://orcid.org/0009-0008-1318-1126)
- Xiangwei Yang (ORCID: https://orcid.org/0000-0001-8824-9596)
- Hui Gao (ORCID: https://orcid.org/0000-0002-7955-1053)
- Feng Wang (ORCID: https://orcid.org/0000-0003-4279-0277)
- Yanzi Chang
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7758-9675)
- Hong Li (ORCID: https://orcid.org/0009-0002-1935-8283)
- Min Jiang (ORCID: https://orcid.org/0000-0002-0839-7992)
- Yanye Tu
Institutions
- Red Cross Hospital (GR)
- Ninghai County First Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fmicb.2025.1628592
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo
- Natural Science Foundation of Zhejiang Province