Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling
S1P alleviated colitis by maintaing the intestinal epithelial integrity, promoting the polarization of M2 macrophage, suppressing chemokines, and regulating PI3K/Akt signaling pathway.
Authors
- Zhichao Chang
- Liang Hu (ORCID: https://orcid.org/0000-0003-1595-8556)
- Xiangchun Li
- Zhaochen Shan (ORCID: https://orcid.org/0000-0003-3990-9011)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6394-3231)
- Zi Yang
- Conglin Du
- Yang Yang (ORCID: https://orcid.org/0000-0002-8737-590X)
Institutions
- Capital Medical University (CN)
- Cells Therapy (Poland) (PL)
- Beijing Obstetrics and Gynecology Hospital (CN)
- First Hospital of Qinhuangdao (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1622094
- Citations
- 2
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Capital Medical University