The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification
In summary, our study provided strong evidence for the prognosis and clinical management of the newly defined GBM from bioinformatics and experimental analysis. Furthermore, our findings provided a foundation for future research targeting pyroptosis and its immune microenvironment to improve GBM prognosis.
Authors
- Xiaohong Zheng (ORCID: https://orcid.org/0000-0002-3027-1042)
- Can Wang (ORCID: https://orcid.org/0000-0002-6467-9097)
- Wenbin Li (ORCID: https://orcid.org/0000-0001-7638-4395)
- Zhangchi Pan
- Lina Chen (ORCID: https://orcid.org/0000-0003-2015-7112)
Institutions
- Fujian Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1617036
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00