A real-world study of the optimal cut-off value for vancomycin trough concentration associated with outcomes in children infected with drug-resistant Gram-positive bacteria
A vancomycin trough concentration above 6.8 mg/L is sufficient to support favorable outcomes in children who were infected with drug-resistant Gram-positive bacteria. Compared with vancomycin-associated AKI, augmented renal clearance and subsequent poor antibiotic treatment outcome deserve more attention.
Authors
- Jingxing Yang (ORCID: https://orcid.org/0000-0002-9390-2104)
- Zengyan Zhu
- Yinghui Yan
- Mi Zhou (ORCID: https://orcid.org/0000-0003-4161-0107)
- Manli Wang (ORCID: https://orcid.org/0000-0001-8701-3530)
- Fengjiao Wang (ORCID: https://orcid.org/0000-0001-5068-1906)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Soochow University (CN)
- Suzhou Institute of Systems Medicine (CN)
- Children's Hospital of Suzhou University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fped.2025.1597306
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Pharmaceutical Association
- National Natural Science Foundation of China