Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onset
We have detected a considerable number of epigenetic marks with potential relevance to the pathogenesis of RA. These findings may pave the way for the development of narrowly targeted new drugs and possibly assist to retrieve persons at particular risk of acquiring RA.
Authors
- Hanne Lindegaard (ORCID: https://orcid.org/0000-0002-5675-3859)
- Anders Jørgen Svendsen (ORCID: https://orcid.org/0000-0002-3481-9001)
- George Davey Smith (ORCID: https://orcid.org/0000-0002-1407-8314)
- Kirsten Ohm Kyvik (ORCID: https://orcid.org/0000-0003-2981-0245)
- Qihua Tan (ORCID: https://orcid.org/0000-0003-3194-0030)
- Jonas Mengel‐From (ORCID: https://orcid.org/0000-0003-1573-8908)
- Peter Junker (ORCID: https://orcid.org/0000-0002-2684-9964)
- Hannah R. Elliott (ORCID: https://orcid.org/0000-0002-1500-3533)
- Caroline L. Relton (ORCID: https://orcid.org/0000-0003-2052-4840)
- Christine Dalgård (ORCID: https://orcid.org/0000-0001-8184-3429)
- Anne Friesgaard Christensen (ORCID: https://orcid.org/0000-0001-7913-0219)
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- University of Bristol (GB)
- Lillebaelt Hospital (DK)
- Svendborg Sygehus (DK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1488161
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gigtforeningen
- Medical Research Council