Hesperidin loaded bilosomes mitigate the nephrotoxicity induced by methotrexate; biochemical and molecular in vivo investigations
Our novel HES-BS nanoformula had potent nephroprotective activity by reducing the toxic effects of MTX treatment by improving biochemical indicators of kidney function, oxidative stress markers, anti-apoptotic gene expression, and apoptotic gene expression, as well as histopathological improvement.
Authors
- Shaymaa Mahmoud (ORCID: https://orcid.org/0000-0001-5497-6429)
- Ahmed F. Azmy (ORCID: https://orcid.org/0000-0002-7347-9564)
- Walaa A. Moselhy (ORCID: https://orcid.org/0000-0003-0173-3292)
- Fatma I. Abo El-Ela
Institutions
- Beni-Suef University (EG)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s12882-025-04328-4
- Citations
- 2
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Beni-Suef University