Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach
Peculiar alterations are observed when each enzyme of the PP is overexpressed, strongly supporting the use of human iPSC-derived astrocytes overexpressing the PP pathway enzymes as a valuable cellular model for understanding how Ser glial metabolism occurs in a non-tumor system under both physiological and pathological conditions.
Authors
- Loredano Pollegioni (ORCID: https://orcid.org/0000-0003-1733-7243)
- Farida Tripodi (ORCID: https://orcid.org/0000-0003-1246-979X)
- Paola Coccetti (ORCID: https://orcid.org/0000-0001-5898-5883)
- Silvia Sacchi (ORCID: https://orcid.org/0000-0002-2338-2561)
- Claudia Bearzi (ORCID: https://orcid.org/0000-0002-8218-9833)
- Valentina Rabattoni (ORCID: https://orcid.org/0000-0001-9550-6220)
- Zoraide Motta (ORCID: https://orcid.org/0000-0003-2254-153X)
- Elisa Maffioli (ORCID: https://orcid.org/0000-0002-5539-1825)
- Gabriella Tedeschi (ORCID: https://orcid.org/0000-0003-2082-6443)
Institutions
- University of Insubria (IT)
- University of Milan (IT)
- Construction Technologies Institute (IT)
- Institute of Biomedical Technologies (IT)
- National Research Council (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fncel.2025.1616911
- Citations
- 1
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Ministero dell'Università e della Ricerca