Esketamine mitigates endotoxin-induced acute lung injury by suppressing caspase-11-driven pyroptosis
Esketamine mitigates CLP-induced ALI by suppressing the caspase-11-GSDMD pathway and reducing inflammation. The PI3K/AKT pathway may be involved in these protective effects.
Authors
- Zhihao Feng (ORCID: https://orcid.org/0000-0002-7123-4678)
- Yunfei Bao (ORCID: https://orcid.org/0000-0002-3477-7921)
- Hongbo Zhang (ORCID: https://orcid.org/0000-0002-1071-4416)
- Jianling Li (ORCID: https://orcid.org/0000-0002-9721-8086)
- Yanyan Niu (ORCID: https://orcid.org/0000-0001-7275-2787)
- Haijie Liu (ORCID: https://orcid.org/0000-0001-8146-2044)
- Qing Hu
Institutions
- Affiliated Hospital of Chengde Medical College (CN)
- Chengde Medical University (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s12871-025-03220-w
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00