The relationship between radiotherapy dose and cognitive outcomes in functional brain network hubs of glioma patients with predominantly left frontal lobe lesions
RT seems to adversely affect left-sided functional hubs in a dose-dependent manner in glioma patients, which may contribute to cognitive dysfunction. Protecting these regions from the dose may potentially mitigate cognitive side effects in glioma patients. However, since most lesions were located in the left hemisphere and baseline testing was unavailable, a potential effect of tumor location cannot be entirely ruled out.
Authors
- Stefan Sunaert (ORCID: https://orcid.org/0000-0002-1177-4680)
- Paul M. Clément (ORCID: https://orcid.org/0000-0001-7600-0806)
- Patrick Dupont (ORCID: https://orcid.org/0000-0003-1980-2540)
- Steven De Vleeschouwer (ORCID: https://orcid.org/0000-0002-9576-9917)
- Laurien De Roeck (ORCID: https://orcid.org/0000-0002-2571-1816)
- Maarten Lambrecht (ORCID: https://orcid.org/0000-0002-8746-2691)
- Charlotte Sleurs (ORCID: https://orcid.org/0000-0002-4480-8330)
- Rob Colaes (ORCID: https://orcid.org/0009-0009-2553-415X)
Institutions
- Allen Institute for Brain Science (US)
- Tilburg University (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/noajnl/vdaf163
- Citations
- 1
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering