Association of hepatic biomarkers with incident diabetes: a mediation analysis of the triglyceride-glucose index in a large Chinese cohort
Hepatic biomarkers, particularly the ALT/AST ratio, robustly predict diabetes risk in this large cohort, with the TyG index explaining most of this association. These insights reinforce the importance of integrating hepatic and metabolic assessment in preventive strategies to address the growing diabetes epidemic.
Authors
- Bo Li (ORCID: https://orcid.org/0000-0001-5669-1785)
- Yesheng Pan (ORCID: https://orcid.org/0000-0002-5502-8858)
- Zhigang Lu (ORCID: https://orcid.org/0000-0002-2880-7848)
- Tao Liu (ORCID: https://orcid.org/0000-0002-0506-3356)
- Bing Wang (ORCID: https://orcid.org/0000-0002-5749-7068)
- Zhijian Zhu
Institutions
- Shanghai Jiao Tong University (CN)
- Zhongda Hospital Southeast University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s12944-025-02661-z
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71