Exploration of JAK/STAT pathway activation in ulcerative colitis reveals sex-dependent activation of JAK2/STAT3 in the inflammatory response
These findings highlight a heterogeneous but important involvement of the JAK/STAT pathway in UC pathophysiology. The observed sex-specific differences and coordinated activation patterns suggest the value of personalized therapeutic approaches targeting specific components of this pathway.
Authors
- Iria Brocos‐Mosquera (ORCID: https://orcid.org/0000-0002-6471-4892)
- Laura Nieto‐García (ORCID: https://orcid.org/0000-0002-5595-7411)
- Inés Ardao (ORCID: https://orcid.org/0000-0002-1201-4165)
- María José Varela (ORCID: https://orcid.org/0000-0002-2340-3481)
- Sol Porto-Silva
- Manuel Barreiro‐de Acosta (ORCID: https://orcid.org/0000-0001-5915-1477)
- Jose Manuel Brea (ORCID: https://orcid.org/0000-0002-5523-1979)
- Marı́a Isabel Loza (ORCID: https://orcid.org/0000-0003-4730-0863)
- Antón L. Martínez (ORCID: https://orcid.org/0000-0002-1595-3459)
- Cristina Suárez (ORCID: https://orcid.org/0000-0003-4208-935X)
- Mariña Durán-Rubí
- David Moreira (ORCID: https://orcid.org/0000-0002-1171-0169)
- Rocío Ferreiro‐Iglesias (ORCID: https://orcid.org/0000-0002-0469-4332)
Institutions
- Universidade de Santiago de Compostela (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1609740
- Citations
- 3
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- European Commission
- Xunta de Galicia
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación