Tryptophan metabolic reprogramming modulates cytokine networks in nucleos(t)ide analogue-treated chronic hepatitis B patients
The tryptophan metabolites (IAld, PA, 5-HT) were found to correlate with cytokine levels (IL-1β, IL-10), potentially implicating their involvement in immune regulation and antiviral responses. These observations delineate a metabolic-immune framework that may inform future therapeutic development for HBV.
Authors
- Xuedan Gao
- Xinhua Dai (ORCID: https://orcid.org/0000-0001-5827-9233)
- Bei Cai (ORCID: https://orcid.org/0000-0002-2597-4915)
- Yi Li (ORCID: https://orcid.org/0000-0002-5849-6040)
- Xiaojuan Wu (ORCID: https://orcid.org/0000-0001-8606-5347)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Research Center of New Materials (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fcimb.2025.1643636
- Citations
- 3
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- West China Hospital, Sichuan University