Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction of Nitroarenes and Buta-1,3-dienes

A palladium-catalyzed denitrative Mizoroki-Heck reaction between nitroarenes and buta-1,3-dienes has been developed, enabling efficient synthesis of 1,4-diaryl-1,3-butadienes with a high functional group tolerance and moderate to excellent yields. Optimized conditions employing Pd(acac)₂/BrettPhos as the catalyst in the presence of CsF in PhCF₃ facilitate selective terminal C-C coupling. The substrate scope encompasses diverse nitroarenes (electron-rich, -poor, heterocyclic) and dienes, demonstrating broad applicability. Postfunctionalization of products further underscores the method's utility in constructing complex aryl-substituted dienes.