Elevated serum total immunoglobulin E is associated with an increased risk of lung cancer: a retrospective study
Lung cancer patients demonstrated elevated serum total IgE levels. Higher serum IgE levels were significantly associated with an increased risk of lung cancer. Therefore, serum total IgE level is a potential diagnostic biomarker for lung cancer. Moreover, IgE and its related allergic immune responses offer potential as innovative therapeutic targets in elderly lung cancer patients with an history of smoking and elevated monocyte counts.
Authors
- Dongmei Zhou (ORCID: https://orcid.org/0000-0002-7917-7954)
- Jin Suk Kang (ORCID: https://orcid.org/0000-0002-4137-5453)
- Zihan Meng (ORCID: https://orcid.org/0000-0002-6439-2838)
- Jia Liu (ORCID: https://orcid.org/0000-0001-6046-0664)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0001-9775-2417)
- Chu Zhang (ORCID: https://orcid.org/0000-0001-6760-3154)
- Dan Kang
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1637803
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Medical University