TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury
Our finding demonstrates that TREM-1 critically mediates neuroinflammation and synaptic dysfunction after TBI. Pharmacological targeting of TREM-1 attenuates neuroinflammation, reduces cerebral edema, preserves blood-brain barrier integrity, and improves functional recovery. These effects are mediated through suppression of TREM-1-dependent NF-κB signaling and pyroptosis. These results highlight TREM-1 as a promising therapeutic target for TBI.
Authors
- Yang Xu (ORCID: https://orcid.org/0000-0001-8778-3885)
- Yulian Zhang (ORCID: https://orcid.org/0000-0003-0752-1522)
- Chuanpeng Zhang (ORCID: https://orcid.org/0009-0000-0283-3063)
- Hanhan Dang (ORCID: https://orcid.org/0009-0009-5019-9584)
- Yunsheng Zhang (ORCID: https://orcid.org/0000-0001-5630-4570)
- Li Zhang (ORCID: https://orcid.org/0000-0003-1637-2522)
- Zixi Wang (ORCID: https://orcid.org/0009-0002-2209-3247)
- Kun He (ORCID: https://orcid.org/0000-0002-6969-3488)
- Yanbing Yu (ORCID: https://orcid.org/0000-0002-3317-060X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1636917
- Citations
- 2
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59