A multimodal nomogram for benign-malignant discrimination of lung-RADS ≥4A nodules: integration of oxygen enhanced zero echo time MRI, CT radiomics, and clinical factors
The nomogram combining OE-ZTE-MRI/CT radiomics and clinical factors (nodule diameter, calcification) improves preoperative discrimination of Lung-RADS ≥4A nodules (AUC=0.838), outperforming single-modality models. This tool enables evidence-based triage, potentially reducing unnecessary invasive procedures.
Authors
- Yuxin Li (ORCID: https://orcid.org/0009-0005-1892-891X)
- Tong Zhang (ORCID: https://orcid.org/0000-0003-1123-7874)
- Tiancai Yan
- Haonan Guan (ORCID: https://orcid.org/0000-0002-4832-5758)
- Chunhui Qin
- Ling Liu (ORCID: https://orcid.org/0009-0005-8358-8165)
Institutions
- Harbin Medical University (CN)
- General Electric (Spain) (ES)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fonc.2025.1563073
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China