Well‐Being, Inflammation, and Physical Activity in Acute and Chronic Back Pain: A Cross‐Sectional Analysis of 22,864 <scp>UK</scp> Biobank Participants

Individuals with acute back pain showed 2% higher CRP than controls, though values remained within the normal range (< 5 mg/L) across groups and below clinical relevance, suggesting limited utility of CRP in distinguishing acute from chronic back pain. Poorer well-being in both acute and chronic back pain underscores the need to explore underlying causal pathways. Moreover, similar network structures among groups indicate no neuroimmune involvement in back pain onset or chronification based on the variables examined.