Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network
Cephalosporins can cause self-limited, mixed/cholestatic hepatitis that arises after a short course of therapy with a latency of up to 3 weeks with cefazolin. Cephalosporin-induced liver injury is associated with the HLA-A*02:01 allele, which is linked to more severe liver injury at the onset of illness.
Authors
- Christopher Koh (ORCID: https://orcid.org/0000-0002-4755-5607)
- Huiman Barnhart
- Raj Vuppalanchi (ORCID: https://orcid.org/0000-0003-0637-1577)
- Yi‐Ju Li (ORCID: https://orcid.org/0000-0001-6996-4834)
- Don C. Rockey (ORCID: https://orcid.org/0000-0002-3751-2961)
- Dina Halegoua‐DeMarzio
- Robert J. Fontana (ORCID: https://orcid.org/0000-0001-9161-5892)
- Herbert L. Bonkovsky
- Joseph A. Odin (ORCID: https://orcid.org/0000-0003-0923-5685)
- Jay H. Hoofnagle
Institutions
- Atrium Health Wake Forest Baptist (US)
- Thomas Jefferson University (US)
- Medical University of South Carolina (US)
- Duke University (US)
- University of Michigan (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Michigan United (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1111/apt.70284
- Citations
- 3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- University of Southern California
- Thomas Jefferson University
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases