Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis
Our results demonstrate a molecular mechanism by which muscle-liver crosstalk can initiate and sustain liver regeneration via the FGF6-FGFBP1/FGF5 axis, providing a potential therapeutic target and treatment strategy for ALI.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8693-3060)
- Xinran Ma (ORCID: https://orcid.org/0000-0003-4968-6536)
- Lanxin Li (ORCID: https://orcid.org/0000-0002-5607-272X)
- Meiyao Meng (ORCID: https://orcid.org/0009-0008-8175-9196)
- Ying Xu (ORCID: https://orcid.org/0000-0002-6689-7768)
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4314-2386)
- Qiurong Ding (ORCID: https://orcid.org/0000-0001-9906-6787)
- Liangjun You
- Xiaohua Chen (ORCID: https://orcid.org/0000-0002-5722-705X)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6303-5858)
- Hong Zhang (ORCID: https://orcid.org/0000-0001-7900-9363)
- Rong Zhang (ORCID: https://orcid.org/0000-0003-1188-0640)
- Xin Li (ORCID: https://orcid.org/0000-0001-6432-3966)
- Caizhi Liu
Institutions
- Xian Central Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Jinan Stomatological Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- East China Normal University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1186/s40779-025-00618-y
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Natural Science Foundation of China