Circulating miRNAs correlate with clinical evaluation of activity in ANCA-associated glomerulonephritis

This study supports serum miRNA profiling as an adjunct noninvasive biomarker for assessing disease activity in AAV-GN. Such an approach could provide complementary information alongside traditional biomarkers and refine the future management of AAV-GN. However, it is important to acknowledge that our actual study cohort was small due to challenging technical aspects of miRNA expression analysis in the serum. Therefore, further research with larger cohorts is required to validate these results and assess their clinical applicability.

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Publication Details

Journal
European journal of medical research
Published
2025-07-21
DOI
https://doi.org/10.1186/s40001-025-02905-9
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00

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article

Circulating miRNAs correlate with clinical evaluation of activity in ANCA-associated glomerulonephritis

Matic Bošnjak, Emanuela Boštjančič, Živa Pipan Tkalec, Nika Kojc et al.
European journal of medical research
Vasculitis and related conditions
article

Circulating miRNAs correlate with clinical evaluation of activity in ANCA-associated glomerulonephritis

Matic Bošnjak, Emanuela Boštjančič, Živa Pipan Tkalec, Nika Kojc, Željka Večerić‐Haler
article en

Abstract

This study supports serum miRNA profiling as an adjunct noninvasive biomarker for assessing disease activity in AAV-GN. Such an approach could provide complementary information alongside traditional biomarkers and refine the future management of AAV-GN. However, it is important to acknowledge that our actual study cohort was small due to challenging technical aspects of miRNA expression analysis in the serum. Therefore, further research with larger cohorts is required to validate these results and assess their clinical applicability.

European journal of medical researchVol. 30(1)
University of Ljubljana (SI), Ljubljana University Medical Centre (SI)
Javna Agencija za Raziskovalno Dejavnost RS, Univerza v Ljubljani, Univerzitetni Klinični Center Maribor
Zero hunger
Openalex Percentile: Top 72%
Vasculitis and related conditions
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