Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome

Higher values of SII and SIRI are related to an elevated risk of ACM and CVM in U.S. adults with CKM syndrome. SIRI had moderate, stable predictive capacities for ACM and CVM, whereas SII exhibited moderate to poor predictive capacity for both outcomes, with SIRI consistently outperforming SII across all evaluated time points. These outcomes highlight these inflammatory markers' potential in forecasting adverse mortality outcomes in this population.