Clinical and biological characteristics associated with loss-of-heterozygosity in endometrial cancer
In this large multiethnic cohort, 17% of EC exhibited high LOH and correlated with hormone-receptor-negative tumors and poorer survival rates. LOH may serve as a tool for identifying EC cases with high genomic instability that could potentially benefit from PARP inhibitors.
Authors
- Caroline Siew Yin Eng (ORCID: https://orcid.org/0000-0001-9805-3730)
- Félix Blanc‐Durand (ORCID: https://orcid.org/0000-0002-5277-1515)
- Etienne Rouleau (ORCID: https://orcid.org/0000-0002-5955-7968)
- Alexandra Léary (ORCID: https://orcid.org/0000-0002-2043-2244)
- Natalie Y.L. Ngoi (ORCID: https://orcid.org/0000-0003-2071-0715)
- David S.P. Tan (ORCID: https://orcid.org/0000-0001-9087-5262)
- Yi Wan Lim (ORCID: https://orcid.org/0000-0003-4823-5151)
- Patricia Pautier (ORCID: https://orcid.org/0000-0001-9904-3040)
Institutions
- National University of Singapore (SG)
- Institut Gustave Roussy (FR)
- National University Cancer Institute, Singapore (SG)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3802/jgo.2026.37.e10
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National University of Singapore
- Foundation Medicine
- Medical Research Council
- National Medical Research Council