Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data

In our small study conducted with open-access data, ASCT2 and LAT1 did not appear to have prognostic value. However, both ASCT2 and LAT1 staining were increased at the endothelium compared to normal brain tissue. These amino acid transporters may play an important role in tumor proliferation and support theranostic approaches to glioma.

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Publication Details

Journal
Cureus
Published
2025-07-19
DOI
https://doi.org/10.7759/cureus.88325
Primary Topic
Amino Acid Enzymes and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data

Najib Muhammad, Nina Cheng, John Y. K. Lee, Wei Han
Cureus
Amino Acid Enzymes and Metabolism
article

Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data

Najib Muhammad, Nina Cheng, John Y. K. Lee, Wei Han
article en

Abstract

In our small study conducted with open-access data, ASCT2 and LAT1 did not appear to have prognostic value. However, both ASCT2 and LAT1 staining were increased at the endothelium compared to normal brain tissue. These amino acid transporters may play an important role in tumor proliferation and support theranostic approaches to glioma.

CureusVol. 17(7)
University of Pennsylvania (US)
Zero hunger
Openalex Percentile: Top 82%
Amino Acid Enzymes and Metabolism
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