Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis
This study provides novel insights into the testicular alterations associated with GAHT in transfemales, particularly highlighting the role of germline-Sertoli cell interactions in testicular injury. Our findings contribute to a deeper understanding of the testicular response to feminizing hormones, offering a foundation for future therapeutic strategies.
Authors
- Yiwen Zhou (ORCID: https://orcid.org/0000-0002-2794-9449)
- Wenming Xu
- Liandong Zuo
- Hao Chen (ORCID: https://orcid.org/0000-0001-8319-8101)
- Yang Liu (ORCID: https://orcid.org/0000-0002-8928-8674)
- Jun Yu (ORCID: https://orcid.org/0000-0003-3109-4102)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0001-5155-8475)
- Xue Wang (ORCID: https://orcid.org/0000-0001-8967-6717)
- Xia Li (ORCID: https://orcid.org/0000-0001-8665-7983)
- Huixia Li (ORCID: https://orcid.org/0000-0001-8566-7143)
- Yongxin Liu (ORCID: https://orcid.org/0000-0003-1832-9835)
- Ting Jiang (ORCID: https://orcid.org/0000-0002-5599-0510)
- Chaoye Ma
- Haocheng Lin (ORCID: https://orcid.org/0000-0002-5333-6611)
- Longfei Hu
Institutions
- Nantong University (CN)
- Peking University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Singleron Biotechnologies (china) (CN)
- Peking University Shenzhen Hospital (CN)
- Peking University Third Hospital (CN)
- Hainan Medical University (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1186/s13578-025-01445-3
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China