Integrative network pharmacology and experimental validation reveal emodin derivatives as potential therapeutics for hepatocellular carcinoma
These findings highlight TAEM as a promising therapeutic candidate for HCC. The study demonstrates the value of integrating computational predictions with experimental validation in early-stage drug discovery.
Authors
- Lalu Muhammad Irham (ORCID: https://orcid.org/0000-0002-0091-4887)
- Nuralih Nuralih
- Firdayani Firdayani
- Wirawan Adikusuma (ORCID: https://orcid.org/0000-0001-9165-690X)
- Shelvi Listiana
- Suci Zulaikha Hildayani (ORCID: https://orcid.org/0000-0002-6164-1675)
- Eko Mugiyanto
- Siska Andrina Kusumastuti (ORCID: https://orcid.org/0000-0002-6270-3356)
- Ayu Masyita (ORCID: https://orcid.org/0000-0001-9388-8528)
- Siti Hodijah
Institutions
- IPB University (ID)
- Universitas Ahmad Dahlan (ID)
- Center for Plant Conservation (US)
- Universitas Pekalongan (ID)
- National Nuclear Energy Agency of Indonesia (ID)
- Federal Agency for Scientific Organizations (RU)
Publication Details
- Journal
- Journal of the Egyptian National Cancer Institute
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1186/s43046-025-00306-x
- Citations
- 1
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Badan Riset dan Inovasi Nasional
- Lembaga Pengelola Dana Pendidikan
- National Cancer Institute