Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances
These data reinforce the importance of the GH/IGF-1 axis in metabolic control and emphasize the relevance of its fine-tuned control by Pappa2. Moreover, the differences between sexes in metabolic imbalances underscore the relevance of sex-specific strategies for treatment of metabolic imbalances.
Authors
- Fernando Rodrı́guez de Fonseca (ORCID: https://orcid.org/0000-0002-4516-5795)
- Juan Suárez (ORCID: https://orcid.org/0000-0001-5254-9802)
- María del Mar Fernández‐Arjona (ORCID: https://orcid.org/0000-0001-5673-9806)
- Antonio J. López-Gambero (ORCID: https://orcid.org/0000-0001-7716-9056)
- Vicente Barrios (ORCID: https://orcid.org/0000-0002-5507-7545)
- Marialuisa de Ceglia (ORCID: https://orcid.org/0000-0003-4256-7702)
- Julie A. Chowen (ORCID: https://orcid.org/0000-0002-4770-2291)
- Patricia Rivera (ORCID: https://orcid.org/0000-0002-0478-6667)
- Ana Campillo-Calatayud (ORCID: https://orcid.org/0000-0003-0017-1048)
- Jesús Argente (ORCID: https://orcid.org/0000-0001-5826-0276)
- Leticia Rubio (ORCID: https://orcid.org/0000-0002-8233-624X)
- Antonio Vargas
- Carlos Vera-Fernández
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Hospital Infantil Universitario Niño Jesús (ES)
Publication Details
- Journal
- Metabolism
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1016/j.metabol.2025.156355
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- Fondation pour la Recherche Médicale
- Ministerio de Economía y Competitividad
- Ministerio de Ciencia e Innovación
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III
- European Regional Development Fund