Zanamivir exposure in healthy rats and rats with acute lung injury
Our findings confirm PK superiority of INH administration to achieve local intrapulmonary exposition and indicate that ALI significantly impairs zanamivir penetration into the lungs from systemic circulation.
Authors
- Ondřej Slanař (ORCID: https://orcid.org/0000-0002-5357-7562)
- Vít Perlík
- Aleš Bartůněk
- Pavel Michálek (ORCID: https://orcid.org/0000-0001-8119-5927)
- Karel Chalupský (ORCID: https://orcid.org/0000-0001-6890-6464)
- Martina Nora Odložilíková
- Helena Mertlíková‐Kaiserová (ORCID: https://orcid.org/0000-0002-2109-4400)
- Pavel Ryšánek (ORCID: https://orcid.org/0000-0001-6727-1663)
- Martin Šíma (ORCID: https://orcid.org/0000-0002-6541-738X)
- Alexandra Dvořáková
- Michaela Sklenárová
- Jaroslava Šmardová (ORCID: https://orcid.org/0000-0001-6003-6441)
- Anežka Klouček
Institutions
- Synlab Czech (Czechia) (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
- General University Hospital in Prague (CZ)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-07-20
- DOI
- https://doi.org/10.1080/07853890.2025.2534523
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Univerzita Karlova v Praze
- Ministerstvo Zdravotnictví Ceské Republiky